Bradykinesia, Rigidity and Gait Disturbance Due to "Possible" Normal Pressure Hydrocephalus in a Patient with Anxiety and Bipolar Disorder : A Case Report / 정신신체의학

In addition to classical triad such as gait disturbance, urinary incontinence and dementia, parkinsonian extrapyramidal motor signs and neuropsychiatric symptoms can be observed in patients with normal pressure hydrocephalus (NPH). In our case, a 46 year old female patient showed extrapyramidal symptoms such as bradykinesia, rigidity and neuropsychiatric symptoms such as agitation, anxiety, restlessness and regressed behavior beside two(gait disturbance & urinary incontinence) symptoms of three classical triad. It was difficult to diagnose this patient as NPH from the beginning because of her relatively young age and previous psychiatric mediation history for controlling advanced anxiety and affective disorder. Antiparkinsonian agents and discontinuation of psychiatric medications did not work for this patient. Patient's brain computed tomographic finding showed enlarged ventricles. We suspected NPH and did empirical drainage of 30mL CSF. Finally, patient's pyramidal and neuropsychiatric symptoms as well as two of three classical triad of NPH were improved dramatically within several days. It is important to consider NPH as one of the differential diagnosis in patient with parkinsonian symptoms and various neuropsychiatric symptoms who did not respond to usual clinical management especially in case of ventricular enlargement in neuroimaging because of its treatable property by CSF shunt operation.

Expression Pattern and Prognostic Correlation of BAG - 1 Protein in Breast Cancer / 대한암학회지

PURPOSE: The objective of this study was to understand the expression of BAG-1 in the human breast cancer. MATERIALS AND METHODS: We studied its expression in one hundred and thirteen patients diagnosed with breast cancer in Dong-A university hospital between 1992 and 1996 by performing immunohistochemical staining with BAG-1 monoclonal antibody. RESULTS: Of the 113 breast carcinoma examined, 62.0% were positive for BAG-1 cyto- plasmic expression, 28.0% were positive for nuclear BAG-1 expression and 9.7% were positive for both BAG-1 cytoplasmic and nuclear expression. The higher histologic grade was correlated with the higher cytoplasmic expression (p<0.05). Except for histologic grade, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, menopausal status, metastatic status of the axillary lymh nodes, cathepsin-D, p53, C-erbB-2, DNA ploidy, S-phase fraction, PCNA (proliferating cell nuclear antigen). CONCLUSION: The high histologic grade was found to correlate with positive BAG-1 cyto- plasmic staining which did not correlate with conventional prognostic factors. Our data indicate that furthermore investigation is warranted to define the role of BAG-1 as an meaningful prognostic factor in patients with newly diagnosed breast cancer.

The Significance of C-erbB-2 Oncoprotein Expression as a Prognostic Predictor in Human Breast Cancer / 한국유방암학회지

The immunohistochemical staining for the C-erbB-2 oncoprotein was performed on sections from paraffin embedded tissue blocks of 96 primary breast cancer patient who underwent operation in our hospital. in order to evaluate the significances as a prognostic factor in the human breast cancer. We investigated the correlation between traditional prognostic factors-patient age, primary tumor size, axillary lymph node metastasis, pathological grade, hormonal receptors (ER &PR)-and C-erbB-2 oncoprotein overexpression. The overall rates of positive staining of C-erbB-2 oncoprotein was 37.5% (36/96). Statistically, the C-erbB-2 positive staining was not correlated with patient age, primary tumor size, axillary lymph node involvement, hormonal receptors, But the high pathologic grade was correlated with C-erbB-2 oncoprotein overexpression and appeared statistically significant (p=0.010). The C-erbB-2 oncoprotein appeared to have prognostic significance in human breast cancer the result.